Synthesis of Compounds Related to Isonicotinic Acid Hydrazide. III

Isonicotinic Acid Hydrazide

Isonicotinic acid hydrazide conversion to Isonicotinyl-NAD by catalase-peroxidases.

Activation of the pro-drug isoniazid (INH) as an anti-tubercular drug in Mycobacterium tuberculosis involves its conversion to isonicotinyl-NAD, a reaction that requires the catalase-peroxidase KatG. This report shows that the reaction proceeds in the absence of KatG at a slow rate in a mixture of INH, NAD(+), Mn(2+), and O(2), and that the inclusion of KatG increases the rate by >7 times. Supe...

Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide

Eight new complexes of Cu(II), Co(II), Ni(II) and Zn(II) with isonicotinic acid hydrazide (isoniazid, (INH)) and isonicotinic acid (1-naphthylmethylene)hydrazide (INNMH), having the formula of the type [M(INH)(ac)2] or [M(INNMH)(ac)2] (M = Co(II), Ni(II) and Zn(II)) and [Cu(INH)(ac)2]2, [Cu(INNMH)(ac)2]2, were synthesized and characterized. All complexes were characterized based on elemental an...

Synthesis and Biological Evaluation of Isonicotinic Acid Hydrazide Conjugated with Diethyelenetriaminepentaacetic Acid for Infection Imaging

Introduction: Isonicotinic acid hydrazide (INH) was coupled to diethylenetriaminepentaacetic acid (DTPA) via amide linkage. Primary object of the present invention was to propose a novel INH derivative based on DTPA, which form stable complexes with most of lanthanides and transition metals in periodic table. Another object of the present invention was to introduce a chelating group in INH with...

Isonicotinic Acid Hydrazide in the Treatment of Lupus Vulgaris